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Common approaches include 4 weeks on followed by 2 weeks off, 6 weeks on followed by 4 weeks off, or running continuously until the injury resolves and then stopping

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A different study also developed a microfluidic device to mimic human microvascular networks using PDMS to culture HUVECs and analyzed the formation of an endothelial surface layer under a physiologically relevant level of fluid shear stress [268]

Low expression of ferroxidases is implicated in the iron retention in human atherosclerotic plaques